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Oxford University Selects Waters Synapt High Definition MS System for Chemical Biology Research
Mass Spectrometry System Will Enable New Research in Understanding How Oxygen
                          Regulates Gene Expression

MILFORD, Mass., Feb. 26 /PRNewswire-FirstCall/ -- Waters Corporation (NYSE: WAT) announced today that Oxford University has taken delivery of a Waters(R) Synapt High Definition MS (TM) System for its Department of Chemistry. The University purchased the system for advanced research in chemical biology and will use it to study interactions between proteins and small molecules and interactions between proteins and other bio- macromolecules.

"We are particularly keen to apply the capability of the Synapt(TM) HDMS System to separate species by ion mobility," commented Prof. Chris Schofield of the Department of Chemistry. "We hope it will enable us to study the effect of binding events on protein conformation in an efficient manner and complement data obtained from high resolution but time-consuming techniques such as X-ray crystallography and NMR. Obtaining three-dimensional information on proteins is difficult to do by existing mass spectrometric-based techniques."

Prof. Schofield also intends to use the Synapt HDMS(TM) System to study multi-component protein complexes. A major aspect of Prof. Chris Schofield's research involves developing a chemical understanding of how cells sense oxygen. In collaboration with researchers in Oxford's Department of Medicine, led by scientists Peter Ratcliffe and Chris Pugh, the scientists have discovered a family of enzymes that act as oxygen sensors in humans. These enzymes catalyze the oxidation of a transcription factor that regulates proteins which in turn increase red blood cell production and blood vessel growth. Applications of this research include learning how to starve cancerous tumors of oxygen and how to oxygenate and, some day, restore heart tissue damaged by various forms of heart disease.

To introduce sample proteins and peptides into the Synapt HDMS System and maintain their conformational state while maximizing productivity and performance, Professor Schofield will use an Advion TriVersa(TM) NanoMate(R) chip-based nanoelectrospray device. Waters Corporation and Advion BioSciences (Ithaca, NY) announced a collaboration in November of 2006 to ensure the compatibility of the TriVersa NanoMate sample introduction device with the Synapt HDMS System. A NanoMate has been successfully used for research at Oxford University in conjunction with a Waters Q-Tof micro(TM) mass spectrometer.

Waters introduced the Synapt HDMS System at the American Society of Mass Spectrometry annual meeting in Seattle in June of 2006. It is the first commercially-available mass spectrometer with the ability to analyze ions by their size, shape and charge in addition to mass.

About the Department of Chemistry at Oxford

The Department of Chemistry is the largest in the western world and graduates 160 chemists annually after a four-year course, which includes a year of research. About 80 graduates receive doctorates.

About Waters Corporation (

Waters Corporation (NYSE: WAT) creates business advantage for laboratory- dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.28 billion in 2006 and 4,500 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

Waters, Synapt, HDMS, High Definition MS, Q-Tof micro and High Definition Mass Spectrometry are trademarks of Waters Corporation. Advion, TriVersa, and NanoMate are trademarks of Advion BioSciences.

    Brian J. Murphy
    Corporate Communications
    Waters Corporation
    +1 508-482-2614

SOURCE  Waters Corporation
    -0-                             02/26/2007
    /Contact:  Brian J. Murphy, Corporate Communications, Waters Corporation,
    /Web site: /

CO:  Waters Corporation; Oxford University
ST:  Massachusetts

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