Novel Approach is Enhancing the Sensitivity of
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Intended for use with Waters ACQUITY® UPLC® M-Class System and a range of Waters mass spectrometers, including the Xevo® TQ-S , Xevo G2-XS and the Synapt® G2-Si, the Waters ionKey/MS System physically integrates a UPLC separation into the mass spectrometer producing up to a 40x improvement in sensitivity, enabling scientists to achieve unparalleled separation and detection of compounds. The ionKey/MS System’s iKey Microfluidic Separation Device, which is about the size of a smart phone, contains the fluidic connections, electronics, ESI interface, column heater, eCord™ Intelligent Chip Technology and the 1.7 micron UPLC grade particles packed inside a 150 micron I.D. channel to perform hundreds upon hundreds of UPLC separations reproducibly and reliably without a degradation in performance.
For quantifying extremely low abundant analytes, researchers often turn to microscale LC techniques employing microfluidics because of their ability to optimize ionization efficiency and improve MS sampling. In their 2014 article in the journal Bioanalysis, Merck scientists beta-testing the ionKey/MS System reported that the method they developed achieved an overall 20-fold increase in sensitivity (0.5 picomoles vs. 11 picomoles) for endogenous levels of GLP-1 in human plasma, a faster run time (nine minutes vs. 35 minutes), increased specificity and resolution over a more traditional LC-MS/MS method.
Since the R&D 100 award competition began, Waters has won nine R&D 100 awards, most recently for its CORTECS® 1.6 micron analytical columns, Oasis® 96-Well (micro) Elution Extraction Plate, XTERRA® Columns, ACQUITY UPLC System and the ACQUITY UPC2® System.
For more information: www.waters.com/ionkey
About the R&D 100 Awards
Widely recognized as the “Oscars of Invention”, the R&D 100 Awards identify and celebrate the top technology products of the year. Past winners have included sophisticated testing equipment, innovative new materials, chemistry breakthroughs, biomedical products, consumer items, and high-energy physics. The R&D 100 Awards spans industry, academia, and government-sponsored research.
For more information www.rdmag.com
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