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Waters Introduces Size Exclusion Chromatography (SEC) Columns for Protein-Based Biotherapeutics Analysis

New Analytical Columns Feature Hybrid Particle Technology and Offer Outstanding Longevity, Batch-to-Batch Consistency and Reproducibility of Results

MILFORD, Mass.--(BUSINESS WIRE)--Oct. 15, 2014-- Waters Corporation (WAT:NYSE) today introduced new size exclusion chromatography (SEC) columns for the characterization of proteins. For use with Waters® Alliance® HPLC, Waters ACQUITY® UPLC® H-Class Systems and other HPLC/UHPLC instruments, the XBridge® Protein BEH SEC Columns deliver optimal throughput and resolution for size-based separations of protein-based biotherapeutics. The columns are immediately available from Waters worldwide.

Waters XBridge Protein BEH SEC Columns are for the chromatographic analysis of protein-based therape ...

Waters XBridge Protein BEH SEC Columns are for the chromatographic analysis of protein-based therapeutics. (Photo: Business Wire)

The XBridge Protein BEH SEC Columns are packed with 3.5 μm particles and are available in either 200 or 450 Å pore sizes for analyzing proteins and other biomolecules ranging in molecular weight from 10,000 – 1,500,000 Da. The columns are designed to operate at higher flow rates and pressures than traditional silica-based SEC columns. These characteristics result in either increased sample throughput or, by using multiple columns in series, greater component resolution. Use of Waters diol-bonded, BEH Technology particles delivers outstanding column longevity and Waters proprietary manufacturing process ensures unmatched batch-to-batch and column-to-column consistency for reproducible results.

These new offerings complement Waters ACQUITY Protein BEH SEC columns and provide laboratories with the ability to seamlessly transfer methods from UPLC to HPLC using columns containing particles differing only in their size. Each batch of XBridge Protein BEH SEC 200 Å and 450 Å, 3.5 μm material is extensively tested to ensure unmatched batch-to-batch consistency.

Each column is shipped with a vial of either the BEH200 or BEH450 SEC Protein Standard Mixture for column and LC System benchmarking, method development, or troubleshooting. These standards are the same as those used for quality control testing of XBridge Protein BEH SEC batches. They may be used to verify the performance of each column upon receipt and to monitor their condition over time.

For more information:

XBridge Protein BEH SEC Columns Product Information:

About Waters Corporation (

For more than 50 years, Waters Corporation has created business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality, consumer products and high-value added chemicals worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.9 billion in 2013, Waters is driving scientific discovery and operational excellence for customers worldwide.

Waters, ACQUITY, ACQUITY UPLC, Alliance and XBridge are trademarks of Waters Corporation.

Source: Waters Corporation

Waters Corporation
Brian J. Murphy, +1 508-482-2614
Public Relations Manager