New Sample Preparation Workflow Produces Exceptionally Clean Samples for Robust and Accurate LC and LC-MS Quantification
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Waters New Oasis PRiME MCX Cartridges and Plates Remove Phospholipids and Other Interferences from Biological Matrices (Photo: Business Wire).
“While it is accepted that sample cleanup provides many benefits, such
as fewer matrix effects and lower limits of detection, many scientists
avoid sample preparation simply because they do not have the time for
method development. They want accurate results faster with the fewest
steps possible,” said
Oasis PRiME MCX is a mixed-mode (reversed-phase and cation exchange) sorbent that addresses the inherent complexities in quantifying target analytes in biological matrices like serum, plasma, whole blood, or human and animal tissue, or food samples including milk, meat and eggs. Furthermore, no conditioning or equilibration steps are required prior to their use, saving scientists significant time and effort. In addition to simplifying analytical workflows, the cleaner samples produced by Oasis PRiME MCX give scientists the same answer time and time again by reducing ion suppression and instrument downtime due to clogged columns and dirty mass spectrometer ion sources. Cleaner samples also translate into longer lasting columns.
Waters’ proprietary manufacturing processes for the cartridges and multi-well plates are optimized to increase flow reproducibility when using positive pressure or vacuum manifolds so that processing times are more predictable. What’s more, for added assurance every batch of sorbent for Oasis PRiME MCX Cartridges and Multi-Well Plates is put through a well-defined, generic, four-step phospholipid removal protocol during the quality control testing process.
Oasis PRiME MCX Cartridges and 96-Well Plates are now available from Waters worldwide. Oasis PRiME MCX joins Oasis PRiME HLB, Ostro™, Sep-Pak®, Oasis HLB and Oasis Mixed Mode IEX in Waters market leading portfolio of sample preparation products.
For more information: www.waters.com/prime
Sample Preparation for High Quality Results
Over the last decade, analytical instrument technology has evolved to the point where limits of detection (LODs) are as low as they have ever been. LC-MS instruments are much more capable of detecting and identifying minute concentrations of sample constituents than ever before. Even so, sample constituents can go undetected and those that aren’t detected, aren’t identified and quantified. Therefore sample preparation has never more been more important than it is today for getting high-quality LC-MS results.
A key to increasing the signal intensity and sensitivity of a mass spectrometer is to remove unwanted sample components – lipids and pigments from a blood or plasma sample for example – that interfere with the signal response of the sample analytes being measured. The removal of matrix interferences from samples is also a proven sure-fire way to prolong column life and the service life of a mass spectrometer.
Waters, Ostro, Sep-Pak and Oasis are trademarks of
Brian Murphy, 508-482-2614
Public Relations Manager